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. 2019 Feb 15;10:207. doi: 10.3389/fimmu.2019.00207

Figure 4.

Figure 4

Highly antigenic HLA class II peptides identified by cultured IFNγ ELISpot assay. Data are shown as the number of individuals recognizing the 50 individual peptides, depending on whether subjects are IGRA- (Group A, no clinical disease, n = 21; gray bars) or IGRA+ (Group B, asymptomatic; Group C, symptomatic; n = 56; black bars). (A) Shows peptide responses reaching a SI ≥2. Bars extending over dotted lines indicate those peptides that were recognized by more than 10% of IGRA- subjects (>2/21) or IGRA+ subjects (>5/56). (B) Shows the stimulation index for each positive response per subject for the 21 highly antigenic peptides identified in (A). Whisker-dot-plots show the interquartile range (25 and 75th percentile) with whiskers extending from min to max values. Numbers indicate the median SI per peptide for IGRA+ subjects.