Table 1.
Cases and strains information of Moesziomyces or Pseudozyma species infections in human.
| No. | strains | Age/sex | Underlying condition | Clinical presentation | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | M. antarcticus | N/A | N/A | N/A | |||||||
| 2 | M. antarcticus | 93/M | Hypertension, chronic renal insufficiency, Alzheimer’s disease, cerebral infarction | COPD | |||||||
| 3 | M. parantarctica | N/A | N/A | N/A | |||||||
| 4 | P. thailandica | N/A | N/A | N/A | |||||||
| 5 | M. aphidis | 7/F | Short gut syndrome | Fever, chill, malaise, and fatigue | |||||||
| 6 | M. aphidis | 51/M | Farmer, chronic leg swelling | Chronic mycetoma of leg | |||||||
| 7 | M. aphidis | 17/M | Burkitt lymphoma, chemotherapy | Neutropenic fever, lung infiltrates | |||||||
| 8 | M. aphidis | 0/M | Hemolytic jaundice | Lethargy, poor feeding | |||||||
| 9 | M. aphidis | 68/F | Adenocarcinoma of ampulla of Vater | Fever, chill | |||||||
| 10 | M. aphidis | 6/F | Osteosarcoma with lung metastasis | Neutropenic fever | |||||||
| 11 | M. aphidis | 51/M | AML, reinduction chemotherapy | Neutropenic fever, lung infiltrates | |||||||
| 12 | P. alboarmeniaca | N/A | N/A | N/A | |||||||
| 13 | P. crassa | N/A | N/A | N/A | |||||||
| 14 | P. siamensis | N/A | N/A | N/A | |||||||
| 15 | Pseudozyma spp. | 78/M | Astrocytoma | Fever after brain surgery | |||||||
| 16 | Pseudozyma spp. | 52/F | Crohn’s disease, total colectomy state | Fever, headache, and weakness | |||||||
| 17 | M. bullatus | 0/F | preterm low birth weight | Low body temperature, jaundice, bilateral pitting pedal oedema | |||||||
| No. | Isolated specimen |
MIC |
Treatment | Country, year (reference) | |||||||
| FLC | ITC | VRC | AMB | CAS | 5FC | ||||||
| 1 | Blood | 0.5 | 0.06 | N/A | 0.12 | N/A | >64 | N/A | Thai, 2003 (Sugita et al., 2003) | ||
| 2 | Blood | 128 | 4 | 8 | <0.5 | N/A | >16 | CAS→LAMB | China, 2018 (This case) | ||
| 3 | Blood | 2 | 0.25 | N/A | 0.25 | N/A | >64 | N/A | Thai, 2003 (Sugita et al., 2003) | ||
| 4 | Blood | >64 | >8 | N/A | 0.25 | N/A | >64 | N/A | Thai, 2003 (Sugita et al., 2003) | ||
| 5 | Blood | 4 | 0.12 | N/A | 0.25 | N/A | N/A | FLC→ITC | United States, 2007 (Lin et al., 2008) | ||
| 6 | Leg | N/A | N/A | N/A | N/A | N/A | N/A | ITC | China, 2011 (Chen et al., 2011) | ||
| 7 | Pleural fluid | 4 | 0.25 | 0.03 | 0.25 | 4 | N/A | LAMB→VRC | Brazil, 2012 (Parahym et al., 2013) | ||
| 8 | Blood | 8 | 0.03 | 0.06 | 0.03 | 8 | >64 | AMB→VRC | India, 2013 (Prakash et al., 2014) | ||
| 9 | Blood | 16 | 0.19 | 0.03 | 0.19 | >32 | >32 | LAMB | France, 2015 (Herb et al., 2015) | ||
| 10 | Blood | 2 | 0.03 | 0.03 | 0.13 | N/A | 128 | LAMB | Argentina, 2013 (Orecchini et al., 2015) | ||
| 11 | Blood | N/A | N/A | N/A | N/A | N/A | N/A | LAMB→VRC | Korea 2015 (Joo et al., 2016) | ||
| 12 | Blood | 32 | 4 | 2 | 0.25 | >16 | >64 | N/A | Thai, 2014 (Mekha et al., 2014) | ||
| 13 | Blood | >64 | 4 | 2 | 0.25 | >16 | >64 | N/A | Thai, 2014 (Mekha et al., 2014) | ||
| 14 | Blood | 32 | 4 | 2 | 0.12 | >16 | >64 | N/A | Thai, 2014 (Mekha et al., 2014) | ||
| 15 | Abscess of brain | N/A | N/A | N/A | N/A | N/A | N/A | N/A | Korea, 2009 (Hwang et al., 2010) | ||
| 16 | Blood | N/A | N/A | N/A | N/A | N/A | N/A | FLC→VRC | United States, 2014 (Siddiqui et al., 2014) | ||
| 17 | Blood | 128 | 0.12 | 0.03 | 1 | 8 | 64 | FLC | Nigeria, 2014 (Ojogba et al., 2015) | ||
FLC, fluconazole; ITC, itraconazole; VRC, voriconazole; AMB, amphotericin B; CAS, caspofungin; 5FC, flucytosine; LAMB, liposomal amphotericin B; N/A, not available.