Table 1.
Effects of simvastatin on the hepatic damage score (HDS) and splenic damage score (SDS) in LPS-induced hepatic and splenic injury in rats.
| Treatment (mg/kg) | 0 | 1 | 2 | 3 | 4 |
 ± S.D. |
|---|---|---|---|---|---|---|
| (A) Hepatic damages score (HDS) (6 livers/group × 6 slices/liver) | ||||||
| Control | 36 | 0 | 0 | 0 | 0 | 0.00 ± 0.00 |
| LPS 0.25 LD50/kg | 0 | 0 | 0 | 13 | 23 | 3.67 ± 0.55 a3 |
| Simvastatin 20 + LPS | 0 | 12 | 14 | 10 | 0 | 2.00 ± 0.89 a1 b2 |
| Simvastatin 40 + LPS | 0 | 15 | 21 | 0 | 0 | 1.50 ± 0.55 b2 |
| (B) Splenic damages score (SDS) (6 spleens/group × 6 slices/spleen) | ||||||
| Control | 36 | 0 | 0 | 0 | 0 | 0.00 ± 0.00 |
| LPS 0.25 LD50/kg | 0 | 0 | 0 | 9 | 27 | 3.75 ± 0.44 a3 |
| Simvastatin 20 + LPS | 0 | 6 | 18 | 12 | 0 | 2.17 ± 0.70 a1 b2 |
| Simvastatin 40 + LPS | 0 | 24 | 12 | 0 | 0 | 1.33 ± 0.48 b2 |
Statistical analysis was performed using the Kruskal–Wallis test. a1, a3 - p < 0.01, 0.001 in comparison to the control group, b2 - p < 0.001 in comparison to the LPS-only treated group.