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. 2019 Feb 15;10:241. doi: 10.3389/fimmu.2019.00241

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Copyright © 2019 Matsumura, Saito, Suzuki, Teramoto, Ozasa, Yamashita, Fujimiya and Saito-Chikenji.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PDGF-BB, TGF-β, and TNF-α stimulation of RA-FLS resulted in predominant pPDGFRαβ expression. (A–C) quantitative data for pPDGFRαβ and CDH11 expression obtained by performing in-cell ELISAs. Stimulation with TNF in addition to 2GF reduced CDH11 expression, but not pPDGFRαβ expression. Stimulation with 2GF reduced the pPDGFRαβ/CDH11 ratio and elevated CDH11 expression. Stimulation with 2GF + TNF caused concentration-dependent increases in the pPDGFRαβ/CDH11 ratio and elevated pPDGFRαβ expression. One-way ANOVA was used for statistical analysis, and the Tukey–Kramer method was used to compare the groups. The significance level was P < 0.05. ^*P < 0.05; ^**P < 0.01.