Table 2.
Comparison of mean FA among the groups from our cohort.
| n1:n2:n3 | AD |
MCI |
NC |
ANOVA |
Post-hoc groupwise (LSD) |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| (N = 25) | (N = 29) | (N = 34) | F | Df | p | AD vs NC | MCI vs NC | AD vs MCI | ||
| ATR_L | 24:29:34 | 0.454 ± 0.044 | 0.453 ± 0.038 | 0.453 ± 0.027 | 0.006 | 86 | 0.994 | 0.924 | 0.997 | 0.924 |
| ATR_R | 25:29:34 | 0.444 ± 0.042 | 0.463 ± 0.03 | 0.460 ± 0.028 | 2.449 | 87 | 0.092 | 0.070 | 0.769 | 0.044 |
| CST_L | 25:29:34 | 0.622 ± 0.044 | 0.620 ± 0.043 | 0.625 ± 0.025 | 0.152 | 87 | 0.859 | 0.750 | 0.588 | 0.846 |
| CST_R | 25:29:34 | 0.615 ± 0.042 | 0.622 ± 0.032 | 0.622 ± 0.031 | 0.345 | 87 | 0.710 | 0.465 | 0.981 | 0.467 |
| CCing_L | 23:28:33 | 0.446 ± 0.067 | 0.461 ± 0.067 | 0.487 ± 0.066 | 2.812 | 83 | 0.066 | 0.024 | 0.127 | 0.423 |
| CCing_R | 20:27:33 | 0.413 ± 0.044 | 0.434 ± 0.049 | 0.466 ± 0.036 | 10.209 | 79 | <0.001⁎⁎ | <0.001⁎ | 0.005⁎ | 0.107 |
| CHippo_L | 9:15:22 | 0.354 ± 0.059 | 0.380 ± 0.058 | 0.389 ± 0.052 | 1.257 | 45 | 0.295 | 0.120 | 0.618 | 0.282 |
| CHippo_R | 12:19:30 | 0.370 ± 0.039 | 0.393 ± 0.052 | 0.394 ± 0.070 | 0.712 | 60 | 0.495 | 0.257 | 0.952 | 0.316 |
| CC Splenium | 21:27:33 | 0.589 ± 0.056 | 0.601 ± 0.043 | 0.613 ± 0.051 | 1.535 | 80 | 0.222 | 0.086 | 0.368 | 0.391 |
| CC Genu | 24:27:34 | 0.503 ± 0.040 | 0.509 ± 0.037 | 0.519 ± 0.039 | 1.173 | 84 | 0.315 | 0.142 | 0.331 | 0.610 |
| IFOF_L | 22:26:34 | 0.438 ± 0.045 | 0.463 ± 0.030 | 0.473 ± 0.034 | 6.582 | 81 | 0.002⁎⁎ | 0.001⁎ | 0.308 | 0.016⁎ |
| IFOF_R | 23:27:31 | 0.433 ± 0.046 | 0.454 ± 0.040 | 0.467 ± 0.030 | 5.180 | 80 | 0.008⁎ | 0.002 | 0.203 | 0.058 |
| ILF_L | 23:29:33 | 0.415 ± 0.030 | 0.436 ± 0.034 | 0.436 ± 0.037 | 3.111 | 84 | 0.050⁎ | 0.028 | 0.989 | 0.032 |
| ILF_R | 24:28:34 | 0.401 ± 0.042 | 0.426 ± 0.037 | 0.415 ± 0.043 | 2.506 | 85 | 0.088 | 0.183 | 0.304 | 0.028 |
| SLF_L | 23:29:34 | 0.427 ± 0.048 | 0.427 ± 0.035 | 0.428 ± 0.051 | 0.015 | 85 | 0.985 | 0.887 | 0.879 | 0.999 |
| SLF_R | 25:29:34 | 0.452 ± 0.050 | 0.459 ± 0.048 | 0.458 ± 0.048 | 0.167 | 87 | 0.846 | 0.623 | 0.957 | 0.600 |
| UF_L | 25:29:34 | 0.406 ± 0.033 | 0.419 ± 0.038 | 0.433 ± 0.034 | 4.384 | 87 | 0.015⁎ | 0.004 | 0.107 | 0.189 |
| UF_R | 24:29:34 | 0.392 ± 0.031 | 0.398 ± 0.035 | 0.416 ± 0.030 | 4.550 | 86 | 0.013⁎ | 0.006 | 0.028 | 0.518 |
| AF_L | 24:28:34 | 0.516 ± 0.055 | 0.522 ± 0.038 | 0.532 ± 0.034 | 1.108 | 85 | 0.335 | 0.148 | 0.377 | 0.560 |
| AF_R | 24:25:33 | 0.492 ± 0.041 | 0.498 ± 0.041 | 0.489 ± 0.039 | 0.345 | 81 | 0.709 | 0.815 | 0.414 | 0.590 |
Note: Data are presented as means ± standard deviations. AD, Alzheimer's disease; MCI, mild cognitive impairment; NC, normal control; ATR, anterior thalamic; CST, corticospinal tract; CCing, cingulum cingulate; CHippo, cingulum hippocampus; CC, corpus callosum; IFOF, inferior fronto-occipital fasciculus; ILF, inferior longitudinal fasciculus; SLF, superior longitudinal fasciculus; UF, uncinated fasciculus. AF, arcuate fasciculus. L, left; R, right. Least significant difference test was used in multiple comparisons. n1: n2: n3 means the successfully traced number of AD, MCI, and NC subjects in each fiber.
Significant difference with a p value <.05 with ANOVA or Post-hoc LSD multiple comparisons.
Significant difference with a p value <.05(FDR corrected).