Table 3.

Comparison of mean MD among the groups from our cohort.

	n1:n2:n3	AD	MCI	NC	ANOVA			Post-hoc groupwise (LSD)
		(N = 25)	(N = 29)	(N = 34)	F	Df	p	AD vs NC	MCI vs NC	AD vs MCI
ATR_L	24:29:34	0.802 ± 0.092	0.771 ± 0.051	0.742 ± 0.04	6.661	86	0.002⁎⁎⁎⁎	<0.001⁎	0.066	0.074
ATR_R	25:29:34	0.778 ± 0.094	0.770 ± 0.076	0.748 ± 0.061	1.210	87	0.303	0.146	0.270	0.699
CST_L	25:29:34	0.774 ± 0.051	0.755 ± 0.030	0.743 ± 0.031	4.845	87	0.010⁎⁎	0.003⁎	0.223	0.066
CST_R	25:29:34	0.759 ± 0.055	0.742 ± 0.031	0.730 ± 0.028	3.892	87	0.024⁎⁎	0.007⁎	0.233	0.118
CCing_L	23:28:33	0.800 ± 0.055	0.790 ± 0.038	0.766 ± 0.040	4.472	83	0.014⁎⁎	0.006⁎	0.039⁎	0.419
CCing_R	20:27:33	0.773 ± 0.045	0.766 ± 0.044	0.741 ± 0.034	4.769	79	0.011⁎⁎	0.007⁎	0.021⁎	0.545
CHippo_L	9:15:22	0.815 ± 0.049	0.786 ± 0.073	0.751 ± 0.044	4.581	45	0.016⁎⁎	0.006⁎	0.067	0.235
CHippo_R	12:19:30	0.795 ± 0.034	0.744 ± 0.054	0.744 ± 0.060	4.274	60	0.019⁎⁎	0.008⁎	0.990	0.013⁎
CC Splenium	21:27:33	0.883 ± 0.085	0.849 ± 0.07	0.853 ± 0.068	1.499	80	0.230	0.148	0.815	0.111
CC Genu	24:27:34	0.845 ± 0.054	0.833 ± 0.057	0.824 ± 0.046	1.154	84	0.320	0.133	0.494	0.419
IFOF_L	22:26:34	0.864 ± 0.059	0.818 ± 0.035	0.798 ± 0.035	16.124	81	<0.001⁎⁎	<0.001⁎	0.072	<0.001⁎
IFOF_R	23:27:31	0.840 ± 0.078	0.800 ± 0.046	0.778 ± 0.033	9.028	80	<0.001⁎⁎	<0.001⁎	0.118	0.010⁎
ILF_L	23:29:34	0.859 ± 0.081	0.824 ± 0.047	0.802 ± 0.039	7.240	85	0.001⁎⁎	<0.001⁎	0.131	0.024⁎
ILF_R	24:28:34	0.811 ± 0.056	0.791 ± 0.057	0.776 ± 0.037	3.495	85	0.035⁎⁎	0.010⁎	0.253	0.143
SLF_L	23:29:34	0.762 ± 0.065	0.747 ± 0.033	0.722 ± 0.029	6.493	87	0.002⁎⁎	0.001⁎	0.022⁎	0.226
SLF_R	25:29:34	0.768 ± 0.052	0.763 ± 0.055	0.747 ± 0.027	1.667	87	0.195	0.091	0.187	0.678
UF_L	25:29:34	0.854 ± 0.043	0.823 ± 0.039	0.808 ± 0.048	8.084	87	0.001⁎⁎	<0.001⁎	0.177	0.011⁎
UF_R	24:29:34	0.843 ± 0.083	0.800 ± 0.042	0.770 ± 0.040	12.133	86	<0.001⁎⁎	<0.001⁎	0.038⁎	0.006⁎
AF_L	24:28:34	0.769 ± 0.055	0.751 ± 0.029	0.733 ± 0.029	6.777	85	0.002⁎⁎	<0.001⁎	0.069	0.071
AF_R	24:25:33	0.759 ± 0.066	0.753 ± 0.035	0.737 ± 0.024	2.130	81	0.126	0.056	0.146	0.649

Note: Unless otherwise specified, data reflect the MD values × 10⁻³ mm² s⁻¹ presented as means ± standard deviations. AD, Alzheimer's disease; MCI, mild cognitive impairment; NC, normal control; ATR, anterior thalamic; CST, corticospinal tract; CCing, cingulum cingulate; CHippo, cingulum hippocampus; CC, corpus callosum; IFOF, inferior fronto-occipital fasciculus; ILF, inferior longitudinal fasciculus; SLF, superior longitudinal fasciculus; UF, uncinated fasciculus; AF, arcuate fasciculus. L, left; R, right. Least significant difference test was used in multiple comparisons. n1: n2: n3 means the successfully traced number of AD, MCI, and NC subjects in each fiber.

^⁎Significant difference with a p value <.05 with Post-hoc LSD multiple comparisons.

^⁎⁎Significant difference with a p value <.05(FDR corrected).