Table 8.
Summary of change in the location of points with significant difference in pointwise comparison of tract profiles across 20 fiber tracts among the groups between our cohort and the ADNI cohort.
| Location of changes in FA |
Location of changes in MD |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AD vs NC |
MCI vs NC |
AD vs MCI |
AD vs NC |
MCI vs NC |
AD vs MCI |
|||||||
| Ours | ADNI | Ours | ADNI | Ours | ADNI | Ours | ADNI | Ours | ADNI | Ours | ADNI | |
| ATR_L | – | – | – | – | – | – | A/M | A | – | – | – | – |
| ATR_R | – | – | – | – | – | – | – | A | – | – | – | – |
| CST_L | – | – | – | – | – | – | S/M | – | – | – | – | – |
| CST_R | – | – | – | – | – | – | S | – | – | – | – | – |
| CCing_L | – | – | – | – | – | – | – | – | – | – | – | – |
| CCing_R | P/M | – | M | – | – | – | P | M | – | – | – | – |
| CHippo_L | – | – | – | – | – | – | P | A | – | – | – | M |
| CHippo_R | – | – | – | – | – | – | – | – | – | – | – | – |
| CC Splenium | L | – | – | – | – | – | – | R | – | – | – | – |
| CC Genu | R | R | – | – | – | – | – | – | – | – | – | – |
| IFOF_L | – | – | – | – | – | – | P/M | M | – | – | P | – |
| IFOF_R | – | – | – | – | – | – | P/M | M | – | – | – | – |
| ILF_L | P | – | – | – | – | A/M | A/M/P | – | – | – | M/P | |
| ILF_R | – | – | – | – | M | – | A | M/P | – | – | – | – |
| SLF_L | – | – | – | – | – | – | A/P | M/P | – | – | – | – |
| SLF_R | – | – | – | – | – | – | – | M/P | – | – | – | – |
| UF_L | F | F | – | – | – | F | M/F | F/M/T | – | – | – | M |
| UF_R | – | – | – | – | – | F | W | – | – | – | M | – |
| AF_L | – | – | – | – | – | – | T/M | M/F | T | – | – | – |
| AF_R | – | – | – | – | – | – | – | – | – | – | – | – |
Note: AD, Alzheimer's disease; MCI, mild cognitive impairment; NC, normal control; ATR, anterior thalamic; CST, corticospinal tract; CCing, cingulum cingulate; CHippo, cingulum hippocampus; CC, corpus callosum; IFOF, inferior fronto-occipital fasciculus; ILF, inferior longitudinal fasciculus; SLF, superior longitudinal fasciculus; UF, uncinated fasciculus; AF, arcuate fasciculus. L, left; R, right. +, difference between the groups; −, no difference between the groups; A, difference in anterior part of the fiber; P, difference in posterior part of the fiber; S, difference in superior part of the fiber; M, difference in middle part of the fiber; T, difference in the temporal lobe part of the fiber; W, difference in the entire fiber. FDR correction was used in comparison in mean FA with a p value<.05. FWE correction was used in point wised location changes with a p value<.05.