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. 2019 Jan 6;243(15-16):1165–1172. doi: 10.1177/1535370218820650

Figure 4.

Figure 4.

SVT attenuates SNP-caused reduction of type II collagen and induction in MMP-1 and MMP-13 expression. Primary rabbit chondrocytes were added with 50 μM SVT for 1 h and then with 1 mM SNP for additional 24 h and analyzed for the expression of MMP-1 (a), MMP-13 (b), and type II collagen (a, b) by immunocytochemistry; DAPI staining was performed for counter staining. MMP: metalloproteinase; SNP: sodium nitroprusside; SVT: simvastatin; CON: control. (A color version of this figure is available in the online journal.)