Figure 2.

Ameliorated effect of MV-miR-451a on HK-2. (a) Cell viability was determined using the CCK-8 assay, and data are expressed as a percentage of the control. (b) HK-2 proliferative ability via BrdU. (c) Cycle changes using control reagent. (d) Representative FACS cell cycle histograms. *P < 0.05, compared with GU group; ^#P < 0.05, compared with MV group. N: 5.5 mM glucose control, GU: 30 mM glucose + 10 mg/dL uric acid, MV: GU + 30 μg MVs, m: GU+100 nM miR-451a mimic, I: GU + 100 nM miR-451a inhibitor, VI: GU+MV + 100 nM miR-451a inhibitor, D: 5.5 mM glucose + 25 mM D-mannitol, H: MVs from Human foreskin fibroblasts (HFF). (A color version of this figure is available in the online journal.)