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. 2018 Nov 26;47(1):453–469. doi: 10.1177/0300060518809255

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© The Author(s) 2018

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — EVs from patients’ HMDMs were taken up by HCAECs. (A) Representative flow cytometry analyses of the EV population derived from HMDMs. (B) Fluorescently-labelled EVs entering HCAECs. Fluorescently-labelled HM-EVs were incubated with HCAECs for 0 (a) or 12 hours (b) at 37°C. Original magnification, ×100; scale bar, 50 µm. (C) Electron microscopy shows that HCAECs (a, b) engulf HM-EVs (arrows). (D) Levels of miR-4306 in HM-EVs in control patients, elective patients, and emergency patients (n = 4). *p < 0.05, **p < 0.01. EV: extracellular vesicle; HM: human monocyte; HMDMs: human monocyte-derived macrophages; HCAECs: human coronary artery vascular endothelial cells; miRNA: microRNA.