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editorial

. 2018 Nov 12;9(4):73–78. doi: 10.4291/wjgp.v9.i4.73

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©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Effect of tumor necrosis factor ligand-related molecule 1 (TL1A) signaling across different subtypes of leukocytes. TL1A acts by promoting cytokine signaling, cell differentiation, and proliferation. These effects vary between different subtypes. While TL1A promotes natural killer T cells and T helper Th1/Th17 proliferation, it can also suppress regulatory T cell functions and forkhead box P3 positive expression. Regardless, TL1A is not associated exclusively with any form. CD: Crohn’s disease; DC: Dendritic cell; DD: Diverticular disease; IFN-γ: Interferon gamma; IL: Interleukin; NKT: Natural killer T cells; TL1A: Tumor necrosis factor Ligand-related molecule 1; Th: T helper; T_reg: Regulatory T cell; Foxp3: Forkhead box P3; UC: Ulcerative colitis.