Table 2.
In vitro activities against G− bacteria of candidates 4g, 4h, and 5d.
| Microorganism Strains No. | Phenotype | 1 (MIC a) | 2 (MIC) | 4g (MIC) | 4h (MIC) | 5d (MIC) | CPFX (MIC) |
|---|---|---|---|---|---|---|---|
| Escherichia coli ATCC 25922 | BL b (+)/ESBLs c (−) | 32 (98.8) | 16 (89.4) | 64 (234) | >64 (>218) | 0.25 (0.478) | ≤0.03 (≤0.0906) |
| E. coli1515 | BL(+)/ESBLs(−) | 32 (98.8) | 16 (89.4) | >64 (>234) | >64 (>218) | 8 (15.3) | ≤0.03 (≤0.0906) |
| Klebsiella pneumoniae ATCC 700603 | ESBLs(+) | >128 (>395) | >64 (>358) | >64 (>234) | >64 (>218) | 8 (15.3) | 0.25 (0.755) |
| K. pneumoniae7 | BL(+)/ESBLs(−) | >128 (>395) | >64 (>358) | >64 (>234) | >64 (>218) | 0.5 (0.956) | ≤0.03 (≤0.0906) |
| K. pneumoniae2146 | NDM-1 d (+) | >128 (>395) | >128 (>715) | >64 (>234) | >64 (>218) | >128 (>245) | >128 (>388) |
| K. pneumoniae12-4 | BL(+)/ESBLs(−) | 128 (395) | >64 (>358) | >64 (>234) | >64 (>218) | 1 (1.91) | ≤0.03 (≤0.0906) |
| K. pneumoniae12-8 | ESBLs(+) | 128 (395) | >128 (>715) | >64 (>234) | >64 (>218) | >128 (>245) | 16 (48.3) |
| Pseudomonas aeruginosa ATCC 27853 | BL(+) | >128 (>395) | >128 (>715) | >64 (>234) | >64 (>218) | 4 (7.65) | 0.5 (1.51) |
| P. aeruginosa PA01 | BL(+) | >128 (>395) | >128 (>715) | >64 (>234) | >64 (>218) | 16 (30.6) | 2 (6.04) |
| P. aeruginosa12-16 | BL(+) | >128 (>395) | >128 (>715) | >64 (>234) | >64 (>218) | >128 (>245) | 4 (12.1) |
| Acinetobacter calcoacetious ATCC 19606 | BL(+) | 128 (395) | 64 (358) | 32 (117) | 64 (218) | 16 (30.6) | 0.5 (1.51) |
| Enterobacter cloacae ATCC 43560 | BL(+) | 128 (395) | 64 (358) | >64 (>234) | >64 (>218) | 8 (15.3) | ≤0.03 (≤0.0906) |
| Enterobacter aerogenes ATCC 13048 | BL(+) | 128 (395) | 128 (715) | >64 (>234) | >64 (>218) | >128 (>245) | ≤0.03 (≤0.0906) |
| Serratia marcescens ATCC 21074 | BL(+) | >128 (>395) | >128 (>715) | >64 (>234) | >64 (>218) | 1 (1.91) | 0.06 (0.181) |
| Morganella morganii ATCC 25830 | BL(+) | >128 (>395) | 64 (358) | >64 (>234) | >64 (>218) | 0.5 (0.956) | ≤0.03 (≤0.0906) |
| Providentia rettgeri ATCC 31052 | BL(-) | >128 (>395) | 16 (89.4) | 64 (234) | >64 (>218) | 0.125 (0.239) | ≤0.03 (≤0.0906) |
| Proteus vulgaris ATCC 29905 | BL(+) | 128 (395) | 64 (358) | 64 (234) | >64 (>218) | 0.125 (0.239) | ≤0.03 (≤0.0906) |
| Proteus mirabilis12-6 | BL(+) | >128 (>395) | 32 (179) | >64 (>234) | >64 (>218) | 64 (122) | 2 (6.04) |
| Stenotrophomonas maltoph.ATCC 13636 | BL(+) | 32 (98.8) | 64 (358) | 64 (234) | >64 (>218) | 128 (245) | 2 (6.04) |
| Citrobacter freundii ATCC 43864 | BL(+) | 64 (198) | 64 (358) | >64 (>234) | NT | 0.5 (0.956) | ≤0.03 (≤0.0906) |
a MIC was determined by agar dilution. MIC unit: μg/mL(μM). b BL, Beta-lactamase; c ESBLs, Extended spectrum beta-lactamase; d NDM-1, New Delhi metallo-beta-lactamase 1.