Table 1.
Effect of solvent on the resolution of 1-phenylethanol a.
| Solvents | Log P b | eep% | ees% | C% | E |
|---|---|---|---|---|---|
| 1,4-Dioxane | −1.1 | 38 | 3 | 5.9 | 2 |
| Acetonitrile | −0.33 | >99 | 3 | 3.2 | 206 |
| Isopropanol | 0.25 | >99 | 1.4 | 1.4 | 202 |
| Tetrahydrofuran | 0.46 | >99 | 5.4 | 5.2 | 210 |
| Methyl tert-butyl ether | 0.96 | >99 | 42 | 29.9 | 300 |
| Isopropyl ether | 1.9 | >99 | 46 | 31.8 | 316 |
| Toluene | 2.5 | >99 | 56 | 36.2 | 351 |
| Hexane | 3.5 | >99 | 88 | 47.1 | 587 |
| Heptane | 4.0 | >99 | 85 | 46 | 546 |
| Isooctane | 4.5 | >99 | 78 | 44.0 | 478 |
a Reactions performed with 5 mg magnetic CALB CLEAs and 2 mL of solvent containing 0.2 mmol of 1-phenylethanol and 0.4 mmol of vinyl acetate at 50 °C for 48 h. b Log P values were cited from Laane et al. [41].