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. 2019 Jan 31;24(3):519. doi: 10.3390/molecules24030519

Figure 5.

Figure 5

Representative example for surface functionalization. (A) Silicon surface of an activated SOI ring resonator. (B) In order to generate an amino-terminated surface, APTES is reacting with the surface siloxane groups. (C) Afterwards, S-HyNic is reacting with primary amines to build a HyNic-displaying surface. (D) Finally, the addition of 4FB-modified antibodies leads to a hydrazone bond formation between the 4FB moieties on the antibodies and the HyNic moieties on the surface. Reprinted (adapted) with permission from Ref. [72]. Copyright (2018) American Chemical Society.