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(a) The c-MYC promoter has one putative G4-forming sequence (PQS). (b) Molecules preferentially interacting with its G4 DNAs over other ones. N-Methylpyrrole is highlighted in blue and N-methylimidazole is highlighted in red. Antitumor activities of TH3, IZCZ-3, benzofuran derivative, and Tz 1 are summarized in Table 1.
