Table 1.
Shared orfs within the cloned biosynthetic gene clusters.
| Proposed Function | A-500359 | A-503083 | A-102395 |
|---|---|---|---|
| Fe(II)- and αKG-dependent dioxygenase | orf7 | capD | cpr18 |
| Capuramycin-2′-O-carbamoyltransferase | orf8 | capB | NA |
| Putative 3-ketoreductase | orf9 | capC | cpr20 |
| Fe(II)-dependent, αKG:UMP dioxygenase | orf10 | capA | cpr19 |
| Putative 2,3-dehydratase | orf11 | capE | cpr21 |
| Putative 4-epimerase | orf12 | capF | cpr22 |
| PLP-dependent monooxygenase-decarboxylase | orf12’ | cap15 | cpr23 |
| Putative glycosyl transferase | orf13 | capG | cpr24 |
| l-Thr:uridine-5′-aldehyde transaldolase | orf14 | capH | cpr25 |
| Putative pyrophosphatase | orf15 | capI | cpr26 |
| Putative CO dehydrogenase | orf16 | capJ | cpr28 |
| Putative O-methyltransferase | orf16’ | capK | cpr29 |
| Putative CO dehydrogenase | orf17 | capL | cpr30 |
| Putative CO dehydrogenase | orf18 | capM | cpr31 |
| Putative ABC transporter | orf19 | capN | NA |
| Putative ABC transporter | orf20 | capO | NA |
| Capuramycin 3′′-phosphotransferase | orf21 | capP | cpr17 |
| UDP-glucose-4,6-dehydratase | orf22 | capQ | NA |
| Glucose-1-phosphate thymidylyltransferase | orf23 | capR | NA |
| Putative carboxyl methyltransferase | orf24 | capS | cpr27 |
| Putative l-ACL C-methyltransferase | orf25 | capT | NA |
| Nonribosomal peptide synthetase | orf26 | capU | NA |
| Nonribosomal peptide synthetase | orf27 | capV | NA |
| Transacylase | orf28 | capW | cpr51 |