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. 2019 Feb 6;24(3):581. doi: 10.3390/molecules24030581

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Potential protein targets of ruthenium(arene) pyridinecarbothioamides (plecstatins) were obtained by integrated target-response profiling. (A) Chemical structures. (B) Schematic representation of the integrated target-response profiling workflow. (C) Selected chromatograms and mass spectra of a plectin-specific tryptic peptide. (D) Plot of the target profiling experiment. PLEC: plectin; ODF2: outer dense fiber protein 2. This figure is adapted from reference [49].