Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic illustration of the effect and mechanism of tariquidar, a P-gp inhibitor, in potentiating the efficacy of ASIV on EAE. P-gp was significantly increased in microvascular endothelial cells from the cortex in EAE mice, which might compromise the efficacy of ASIV on EAE. Coadministration of tariquidar potentiated the neuroprotective effect of ASIV in EAE mice by reducing the efflux of the penetrated ASIV in the CNS.
