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. 2019 Feb 21;9:2500. doi: 10.1038/s41598-019-39199-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Standardized z-scores (mean ± 99% confidence interval) computed across the brain are shown for each measure (MWF, T1w/T2w, FA, AD, RD⁻¹ and MD⁻¹) in each of the 25 ROIs. Each structure is indicated by a different color in order to match the ROIs shown in Fig. 1, and values for RD and MD were inverted (RD⁻¹ and MD⁻¹) prior to z-scoring, in order to produce analogous contrasts (i.e., positive z-scores reflecting greater microstructural integrity and negative z-scores reflecting lower microstructural integrity) across measures.