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. 2019 Feb 22;9:2623. doi: 10.1038/s41598-019-40023-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The phylostratigraphic alignment of co-expression relations’ constrictions in four periods: PS1–PS9, PS10, PS11 and PS12–PS19. Nodes in this module in different phylostratigraphic time-points represent genes, while edges depict two kinds of relations: the co-expressed relations between any two nodes inner one period and phylostratum alignment between genes from diverse phylogenetic time-ponits. Node colors depict gene’s origin time (phylostratigraphic time-points). Edge colors depict gene’s co-expression or phylostratigraphic alignment relation emergence time-points. Edge shapes depict genes’ relation type, the solid line indicate co-expression relation and long dash line means phylostratum alignment.