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. 2019 Feb 22;9:2573. doi: 10.1038/s41598-019-39119-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cochlear afferent synapse counts are normal in K_Na1 DKO mice. Synapses between the spiral ganglion neurons (SGNs) and inner hair cells (IHCs) were quantified at three tonotopic locations (8, 16 and 32 kHz) in organs of Corti isolated from 6-week-old WT and DKO mice. (A) There were no obvious differences between WT and DKO mice in the organization of afferent synapses, identified as paired CtBP2 (green) and GluR2/3-(red) immunopuncta. Images are presented as Z-projections through a stack of confocal micrographs from the 16 kHz region. (B) Quantification of the mean number of synapses per IHC indicated no statistically significant differences between WT (black) and DKO (grey) mice at any of the tonotopic regions. Data are plotted to show individual replicates (animals) and mean ± SEM. Values (mean ± SEM) are provided in Table 2. Statistical analyses are provided in the Results.