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. 2019 Feb 22;9:2573. doi: 10.1038/s41598-019-39119-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Molecular and cellular architecture appears normal in SGNs from K_Na1 DKO mice. The expression and distribution of various proteins shaping SGN excitability were examined using immunofluorescence in the isolated preparation of the organ of Corti and SGNs from (6-week-old) WT and DKO mice. (A) The expression of the Na⁺, K⁺-ATPase α3 (ATP1A3, green) and patterns of myelination were similar in both WT and DKO mice. (B) The expression and distribution of the low voltage-activated K_V1.1 (green) was similar in both WT and DKO mice. Tubulin J (TuJ, red) marks the SGN afferent dendrites and is provided for reference. (C) The expression and distribution of the high voltage-activated K_V3.1 (green) and the voltage-gated Na_V1.6 (red) were similar in both WT and DKO mice. All images are presented as Z-projections through a stack of confocal micrographs from the 16 kHz region. Expression patterns of ATP1A3, MBP, K_V1.1, K_V3.3 and Na_V1.6 were similarly expressed at other regions as well as in the somata of the SGNs from WT and DKO mice.