Figure 7.

CuB inhibits tumor growth in murine models. (A) Murine models were treated with vehicle, gefitinib (Gef, 30 mg/kg), or CuB (0.5 mg/kg) and the tumor volumes were calculated twice a week. ** P < 0.01 vs. vehicle or Gef. (B) Images of xenograft tumors obtained from mice with different treatment after 24 days. (C) Weight of the tumor from each group taken out from the sacrificed mice at the end of the study ** P < 0.01 vs. vehicle or Gef group. (D) CuB treatment did not affect the murine model body weight. (E) The expressions of EGFR and CIP2A in xenograft tumors were analyzed by immunohistochemistry (original magnification 400×), and their expression levels were quantified in percentages of positive cells within five medium-power fields under microscope and shown in histograms; * P < 0.05, ** P < 0.01 compared with the vehicle group.