Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Biosynthesis of tiglic and angelic acid. l-Isoleucine is desaminated and the obtained ketocarboxylic acid decarboxylated to 2-methylbutyric acid, which is likely accompanied by linking with coenzyme A to yield 2-methylbutyryl-CoA. This intermediate is hydroxylated and subsequently dehydrated to form tiglyl-CoA, which can be isomerized to angelyl-CoA. The activated tiglic and angelic acid residues are finally transferred to necine bases and coenzyme A is released.
