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Dafachronic acid synthesis in Caenorhabditis elegans. Sterol nomenclature is given in Table 1. C4-demethylation in eukaryotes: HSD-1, 3-hydroxysteroid dehydrogenase/Δ5/Δ4 isomerase (HSD-1); STRM-1, Sterol 4-C-methyltransferase; DAF-9, steroid cytochrome P450 hydroxylase; DAF-36, cholesterol 7-desaturase. Each arrow represents an enzymatic step.
