Table 1.
Comparison of l-phenylalanine production in different recombinant strains of E. coli
| Strain | Relevant characteristics | Titer (g/L) | Conversion rate (mol/mol) | Productivity (g/L/h) | Culture methods | References |
|---|---|---|---|---|---|---|
| WSH-Z06 (pAP-B03) | E. coli K-12 with l-tyrosine auxotrophic | 35.38 | 26% | N | 3-L fed-batch fermentation | Haiyan et al. (2010) |
| HD-A2 | Multiple random mutagenesis of E. coli W3110 and overexpressing aroFWT, pheAFBR and aroA | 62.47 | 25.74% | N | 5-L fed-batch fermentation | Ding et al. (2016) |
| BR-42 (pAP-B03) | Multiple random mutagenesis of E. coli WSH-Z06 and overexpressing aroFWT and pheAFBR | 57.63 | 26.4% | 1.153 | 3-L fed-batch fermentation | Zhou et al. (2011) |
| Xllp21 | W3110-derived l-tyrosine auxotrophic with overexpressed aroFWT, aroD, and pheAFBR, inactivated tyrR, and genomic integrated galP and glk | 72.9 | 28.3% | N | 5-L fed-batch fermentation | Liu et al. (2018) |
| W3110 (pNpheABK15) | W3110 with overexpressed pheAFBR, ydiB, aroK and aroG15 | 23.8 | 16.8% | 0.073 | 15-L fed-batch fermentation | Liu et al. (2013) |
| pR15BABKG | WSH-Z06△crr with overexpressed pheA, aroG15, ydiB, aroK, tyrB and yddG | 47 | 27.5% | N | 5-L fed-batch fermentation | Liu et al. (2013) |
| W3110-4 (pF20) | W3110 (△pheA△tyrA △aroF) with overexpressed aroFFBR and pheAFBR | 32 | N | N | 300-L fed-batch fermentation | Gerigk et al. (2002b) |
| E. coli aroF-wt | w3110 Fnr+ (△pheA△tyrA △aroF)/pJF119EH-aroFWT-pheAFBR-aroLWT | 35 | N | N | 20-L fed-batch fermentation | Gerigk et al. (2002a) |
N not reported