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. 2019 Jan 26;24(3):437. doi: 10.3390/molecules24030437

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Scheme 1 — Reagents and conditions: (a) SOCl₂, ⁱPrNEt, DCM, reflux, 78–91%; (b) NaH, DMF, PMBCl or MOMCl, rt, 92–98%; (c) Pd(oAc), P(o-tol)₃, K₂CO₃, DMF, 155 °C, 78–90%; (d) TFA, 75 °C, 54–78%; (e) LiAlH₄, dry THF, 0 °C-rt, 45–55%.

Scheme 1 — Reagents and conditions: (a) SOCl₂, ⁱPrNEt, DCM, reflux, 78–91%; (b) NaH, DMF, PMBCl or MOMCl, rt, 92–98%; (c) Pd(oAc), P(o-tol)₃, K₂CO₃, DMF, 155 °C, 78–90%; (d) TFA, 75 °C, 54–78%; (e) LiAlH₄, dry THF, 0 °C-rt, 45–55%.