Scheme 2.
Reagents and conditions: (a) ethyl bromoacetate or ethyl 4-bromobutyrate, Cs2CO3, TBAI, DMF, 90 °C, 76–95%; (b) MeOH, H2O, 10N NaOH, rt, 93–98%; (c) triethylamine, THF, CH2Cl2, isobutyl chloroformate, dimethylamine, 0 °C-rt, 82–85%.
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