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. 2019 Jan 22;24(3):393. doi: 10.3390/molecules24030393

Figure 5.

Figure 5

PI3K/AKT/β-catenin involved SAF-mediated suppression of MARCH1 expression in HCC. (A,B) Western blotting showed the expression of MARCH1, PI3K, P-AKT, β-catenin, Mcl-1, Bcl-2, cleaved caspase-3, and cleaved caspase-7 in HepG2 after 24 h and in Hep3B cells after 48 h of SAF treatment (0, 1.25, 2.5, and 5.0 μM). (C,D) Protein expression of MARCH1, PI3K, P-AKT, β-catenin, Mcl-1, Bcl-2, cleaved caspase-3, and cleaved caspase-7 in HepG2 and Hep3B cells transfected with MARCH1 siRNA (siRNA-1 and siRNA-2), as measured by western blotting. All data were carried out at least three times. All data in this figure are presented as means ± SD.