Figure 1.
Distribution of estimated tumour purity of clear cell, papillary and chromophobe RCC samples for which estimated tumour purity was available and for samples which passed Toil quality control. 1/3 of the ccRCC samples have an estimated tumour purity <60% and 1/3 have an estimated tumour purity >72%. ccRCC have a far lower median estimated tumour purity than papillary and chromophobe RCC samples (both P < 10−16, Wilcoxon rank-sum test). Clear cell RCC samples are still statistically significantly less pure than papillary and chromophobe RCC (P < 1 × 10−11) even after correcting for batch ID (Supplementary Table S1) and tissue source site (Supplementary Table S2) using linear mixed model analysis.