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. 2019 Feb 21;9:2495. doi: 10.1038/s41598-019-39891-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Density plot of the number of overlapping genes between tumour sample signatures and LINCS drug signatures, for the 3 tertiles of the number of genes chromosomally altered in genes that regulate p53 and the G1/S cell cycle transition. The number of genes increases from 0 alterations to 1–3 alterations (P = 9 × 10⁻⁵), from 1–3 alterations to 4–15 alterations (P = 6 × 10⁻⁴) and from 0 alterations to 4–15 alterations is even more significant (P = 1 × 10⁻¹¹, all tested using the Wilcoxon rank-sum test).