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. 2019 Feb 21;9:2495. doi: 10.1038/s41598-019-39891-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mean connectivity score of PX-12 and CAY-10585 plotted against VHL status for the 37 samples which have not lost chromosome 3p and for which both mutation and methylation data is available. Sometimes points with connectivity score 0 are plotted over each other and given the number of samples to the right (i.e. x 2, x 8). VHL mutated or methylated samples (when the 3 types are grouped together) have statistically significantly lower connectivity scores than non-VHL mutated/methylated samples (P = 0.03, Wilcoxon rank-sum test).