Table 3.
Genotype distribution of cytokine genes in the two populations.
| Gene/SNPs | Han population | Tibetan population | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Case(%), n = 636 | Control(%), n = 608 | P # | OR#(95% CI) | Case(%), n = 613 | Control(%), n = 603 | P # | OR#(95% CI) | |||
| IL1B | rs1143634 | Genotype | ||||||||
| GG | 604 (95.6) | 288 (94.4) | 566 (92.3) | 568 (94.4) | ||||||
| GA | 28 (4.4) | 16 (5.2) | 0.094 | 1.71 (0.91–3.19) | 46 (7.5) | 34 (5.6) | 0.184 | 1.37 (0.86–2.16) | ||
| AA | 0 (0) | 1 (0.3) | — | 1 (0.2) | 0 (0.0) | — | ||||
| Allele | ||||||||||
| G | 1236 (97.8) | 592 (97.0) | 1178 (96.1) | 1170 (97.2) | ||||||
| A | 28 (2.2) | 18 (3.0) | 0.183 | 1.50 (0.83–2.73) | 48 (3.9) | 34 (2.8) | 0.133 | 1.41 (0.90–2.21) | ||
| rs16944 | Genotype | |||||||||
| GG | 164 (25.9) | 164 (27.1) | 110 (17.9) | 131 (21.7) | 0.028 | 0.69 (0.50–0.96) | ||||
| GA | 309 (48.9) | 302 (49.9) | 0.463 | 0.90 (0.68–1.19) | 298 (48.6) | 303 (50.2) | 0.105 | 0.81 (0.62–1.05) | ||
| AA | 159 (25.2) | 139 (23.0) | 0.413 | 0.88 (0.64–1.20) | 205 (33.4) | 169 (28.0) | ||||
| Allele | ||||||||||
| G | 637 (50.4) | 630 (52.1) | 518 (42.3) | 565 (46.8) | 0.023 | 0.83 (0.71–0.97) | ||||
| A | 627 (49.6) | 580 (47.9) | 0.422 | 1.07 (0.91–1.25) | 708 (57.7) | 641 (53.2) | ||||
| rs1143623 | Genotype | |||||||||
| CC | 198 (31.3) | 203 (33.6) | 155 (25.3) | 162 (26.9) | ||||||
| GC | 309 (48.9) | 303 (50.1) | 0.709 | 1.05 (0.82–1.35) | 294 (48.0) | 299 (49.7) | 0.731 | 1.05 (0.80–1.38) | ||
| GG | 125 (19.8) | 99 (16.4) | 0.132 | 1.29 (0.93–1.79) | 164 (26.8) | 141 (23.4) | 0.226 | 1.22 (0.89–1.67) | ||
| Allele | ||||||||||
| C | 705 (55.8) | 709 (58.6) | 604 (49.3) | 623 (51.7) | ||||||
| G | 559 (44.2) | 501 (41.4) | 0.163 | 1.12 (0.96–1.31) | 622 (50.7) | 581 (48.3) | 0.222 | 1.10 (0.94–1.30) | ||
| IL6 | rs17147230 | Genotype | ||||||||
| AA | 197 (31.2) | 183 (30.2) | 123 (20.1) | 143 (23.8) | 0.290 | 0.84 (0.61–1.16) | ||||
| AT | 315 (49.8) | 289 (47.8) | 0.214 | 1.21 (0.90–1.62) | 313 (51.1) | 287 (47.7) | 0.665 | 1.06 (0.81–1.38) | ||
| TT | 120 (19.0) | 133 (22.0) | 0.273 | 1.20 (0.87–1.65) | 177 (28.9) | 172 (28.6) | ||||
| Allele | ||||||||||
| A | 709 (56.1) | 655 (54.1) | 559 (45.6) | 573 (47.6) | 0.344 | 0.93 (0.79–1.09) | ||||
| T | 555 (43.9) | 555 (45.9) | 0.328 | 0.92 (0.79–1.08) | 667 (54.4) | 631 (52.4) | ||||
| rs1800795 | Genotype | |||||||||
| GG | 630 (99.7) | 599 (99.0) | 606 (98.9) | 601 (99.7) | ||||||
| GC | 2 (0.3) | 6 (1.0) | 0.161 | 0.32 (0.06–1.58) | 6 (1.0) | 2 (0.3) | 0.185 | 2.96 (0.60–14.74) | ||
| CC | 0 (0) | 0 (0) | — | 1 (0.2) | 0 (0) | — | ||||
| Allele | ||||||||||
| G | 1262 (99.8) | 1204 (99.5) | 1218 (99.3) | 1204 (99.8) | ||||||
| C | 2 (0.2) | 6 (0.5) | 0.161 | 0.32 (0.06–1.58) | 8 (0.7) | 2 (0.2) | 0.082 | 3.97 (0.84–18.74) | ||
| rs2069837 | Genotype | |||||||||
| AA | 443 (70.1) | 392 (64.8) | 340 (55.5) | 338 (56.1) | ||||||
| GA | 163 (25.8) | 183 (30.2) | 0.060 | 0.79 (0.61–1.01) | 226 (36.9) | 213 (35.4) | 0.674 | 1.05 (0.83–1.34) | ||
| GG | 26 (4.1) | 30 (5.0) | 0.328 | 0.76 (0.44–1.31) | 47 (7.7) | 51 (8.5) | 0.697 | 0.92 (0.60–1.41) | ||
| Allele | ||||||||||
| A | 1049 (83.0) | 967 (79.9) | 906 (73.9) | 889 (73.8) | ||||||
| G | 215 (17.0) | 243 (20.1) | 0.046 | 0.81 (0.66–0.99) | 320 (26.1) | 315 (26.2) | 0.972 | 0.99 (0.83–1.20) | ||
| TNF | rs1799964 | Genotype | ||||||||
| TT | 390 (61.7) | 413 (68.3) | 329 (53.7) | 372 (61.8) | ||||||
| CT | 212 (33.5) | 173 (28.6) | 0.037 | 1.30 (0.02–1.66) | 239 (39.0) | 190 (31.6) | 0.004 | 1.43 (1.12–1.82) | ||
| CC | 30 (4.7) | 19 (3.1) | 0.099 | 1.65 (0.91–2.98) | 45 (7.3) | 40 (6.6) | 0.286 | 1.28 (0.81–2.01) | ||
| Allele | ||||||||||
| T | 992 (78.5) | 999 (82.6) | 897 (73.2) | 934 (77.6) | ||||||
| C | 272 (21.5) | 211 (17.4) | 0.011 | 1.30 (1.06–1.58) | 329 (26.8) | 270 (22.4) | 0.011 | 1.27 (1.06–1.53) | ||
| rs1800630 | Genotype | |||||||||
| CC | 410 (64.9) | 431 (71.2) | 372 (60.7) | 417 (69.2) | ||||||
| CA | 199 (31.5) | 157 (26.0) | 0.024 | 1.33 (1.04–1.71) | 208 (33.9) | 157 (26.0) | 0.002 | 1.49 (1.16–1.92) | ||
| AA | 23 (3.6) | 17 (2.8) | 0.312 | 1.39 (0.73–2.65) | 33 (5.4) | 29 (4.8) | 0.359 | 1.28 (0.76–2.14) | ||
| Allele | ||||||||||
| C | 1019 (80.6) | 1019 (84.2) | 952 (77.7) | 991 (82.2) | ||||||
| A | 245 (19.4) | 191 (15.8) | 0.020 | 1.28 (1.04–1.58) | 274 (22.3) | 215 (17.8) | 0.005 | 1.33 (1.09–1.62) | ||
| rs1799724 | Genotype | |||||||||
| CC | 462 (73.1) | 436 (72.1) | 368 (60.0) | 430 (71.3) | ||||||
| CT | 160 (25.3) | 154 (25.5) | 0.889 | 0.98 (0.76–1.27) | 206 (33.6) | 157 (26.0) | 0.001 | 1.53 (1.19–1.97) | ||
| TT | 10 (1.6) | 15 (2.5) | 0.257 | 0.63 (0.28–1.41) | 39 (6.4) | 16 (2.7) | 0.001 | 2.87 (1.58–5.22) | ||
| Allele | ||||||||||
| T | 1084 (85.8) | 1026 (84.8) | 942 (76.8) | 1017 (84.3) | ||||||
| C | 180 (14.2) | 184 (15.2) | 0.499 | 0.93 (0.74–1.16) | 284 (23.2) | 189 (15.7) | <0.001 | 1.62 (1.32–1.99) | ||
| rs1800629 | Genotype | |||||||||
| GG | 541 (85.6) | 510 (84.3) | 587 (95.8) | 560 (93.0) | ||||||
| GA | 88 (13.9) | 92 (15.2) | 0.526 | 0.90 (0.66–1.24) | 25 (4.1) | 42 (7.0) | 0.028 | 0.57 (0.34–0.94) | ||
| AA | 3 (0.5) | 3 (0.5) | 0.954 | 0.95 (1.91–4.75) | 1 (0.2) | 0 (0) | — | |||
| Allele | ||||||||||
| G | 1170 (92.6) | 1112 (91.9) | 1199 (97.8) | 1162 (96.5) | ||||||
| A | 94 (7.4) | 98 (8.1) | 0.545 | 0.91 (0.68–1.23) | 27 (2.2) | 42 (3.5) | 0.056 | 0.62 (0.38–1.01) | ||
| rs361525 | Genotype | |||||||||
| GG | 607 (96.0) | 582 (96.2) | 559 (91.2) | 553 (91.7) | ||||||
| GA | 24 (3.8) | 22 (3.6) | 0.892 | 1.04 (0.58–1.88) | 52 (8.5) | 48 (8.0) | 0.718 | 1.08 (0.72–1.63) | ||
| AA | 1 (0.2) | 1 (0.2) | 0.984 | 0.97 (0.06–15.64) | 2 (0.3) | 2 (0.3) | 0.989 | 0.99 (0.14–7.04) | ||
| Allele | ||||||||||
| G | 1238 (97.9) | 1186 (98.0) | 1170 (95.4) | 1154 (95.7) | ||||||
| A | 26 (2.1) | 24 (2.0) | 0.908 | 1.03 (0.59–1.81) | 56 (4.6) | 52 (4.3) | 0.740 | 1.07 (0.73–1.57) | ||
Abbreviation: SNPs, single nucleotide polymorphisms; CI, confidence interval; OR, odds ratio.
#Adjusted by age and sex status.