Table 5.

Haplotypes of the cytokines genes and their distributions in the two cohorts.

Gene/haplotype	Han population				Tibetan population
	Case(%) n = 1264	Control(%) n = 1210	P	OR	Case(%) n = 1226	Control(%) n = 1210	P	OR
IL1B
AGC	—				46.4 (3.8)	16.62 (1.4)	<0.001	2.82 (1.60–4.96)
GAC	75.4 (6.0)	86.6 (7.2)	0.251	0.83 (0.60–1.42)	91.4 (7.5)	86.6 (7.2)	0.785	1.04 (0.77–1.42)
GAG	551.5 (43.6)	492.1 (40.7)	0.097	1.15 (0.98–1.35)	615.0 (50.2)	492.1 (40.7)	<0.001	1.47 (1.25–1.72)
GGC	601.6 (47.6)	605.8 (50.1)	0.285	0.92 (0.78–1.08)	466.3 (38.0)	605.8 (50.1)	<0.001	0.61 (0.52–0.72)
Other*	35.4 (2.8)	25.6 (2.1)	?	?	7.0 (0.5)	8.9 (0.7)	?	?
IL6
AGA	674.3 (53.3)	615.9 (50.9)	0.259	1.01 (0.94–1.28)	531.0 (43.3)	615.9 (50.9)	<0.001	0.74 (0.63–0.87)
AGG	34.73 (2.7)	39.11 (3.2)	0.470	0.84 (0.53–1.34)	26.62 (2.2)	39.1 (3.2)	0.108	0.67 (0.40–1.10)
TGA	372.8 (29.5)	345.1 (22.7)	0.633	1.04 (0.88–1.24)	367.0 (29.9)	345.1 (28.5)	0.428	1.07 (0.90–1.28)
TGG	180.3 (14.3)	203.9 (16.9)	0.070	0.82 (0.66–1.02)	293.4 (23.9)	203.9 (16.9)	<0.001	1.56 (1.27–1.90)
Other*	2.0 (0.2)	6.0 (0.5)	?	?	8.0 (0.6)	6 (0.5)	?	?
TNF
CACGG	189.0 (15.6)	242.9 (19.2)	0.018	0.78 (0.63–0.96)	271.3 (22.1)	189.0 (15.6)	<0.001	1.54 (1.25–1.89)
CCCGA	—				53.3 (4.3)	22.0 (1.8)	<0.001	2.46 (1.49–4.07)
TCCAG	95.5 (7.9)	93.9 (7.4)	0.666	1.07 (0.79–1.44)	25.2 (2.1)	95.5 (7.9)	<0.001	0.25 (0.16–0.38)
TCCGG	716.6 (59.2)	718.1 (56.8)	0.221	1.11 (0.94–1.30)	591.2 (48.2)	716.6 (59.2)	<0.001	0.64 (0.55–0.75)
TCTGG	181.5 (0.2)	180.0 (14.2)	0.595	1.06 (0.85–1.33)	277.8 (22.7)	181.5 (15.0)	<0.001	1.67 (1.35–2.05)
Other*	27.6 (2.3)	29.1 (2.3)			7.2 (0.5)	5.6 (0.5)

CI, confidence interval; OR, odds ratio.

^*Haplotypes with frequency <0.03 were pooled into this category.