Table 3.
Summary of the multivariate logistic regression analyses for the examined binary dependent variables, i.e. total number of photodynamic therapies with verteporfin (PTD-V) scheduled in each patient during the 24-month follow-up period (TN-PDT-V), and change of best-corrected visual acuity from baseline to final visit (∆-BCVA). PDT-V, photodynamic therapy with verteporfin; BCVA, best correct visual acuity; OR, odds ratio; CI, confidence intervals; CNV, choroidal neovascularization; MTHFR, methylenetetrahydrofolate reductase; NR, not relevant; NS, not significant.
| Independent variables | Dependent variable TN-PDT-V | Dependent variable ∆-BCVA | ||
|---|---|---|---|---|
| P value | OR (95% CI) | P value | OR (95% CI) | |
| Patient’s age per 3-year increment | 0.02 | 1.13 (1.02–1.26) | NS | NR |
| Baseline BCVA | NS | NR | NS | NR |
| Baseline CNV area | 0.01 | 0.80 (0.68–0.96) | NS | NR |
| MTHFR-C677T CT genotype | 0.001 | 0.19 (0.12–0.32) | 0.001 | 0.24 (0.15–0.39) |
| MTHFR-C677T TT genotype | 0.001 | 0.09 (0.04–0.21) | 0.001 | 0.03 (0.01–0.11) |