Skip to main content
. 2019 Feb 21;9:2436. doi: 10.1038/s41598-019-38857-4

Figure 1.

Figure 1

The structural organization of prothrombin. Prothrombin consists of fragment 1 (F1), which contains the γ-carboxyglutamic (GLA) and kringle 1 (K1) domains, fragment 2 (F2), which contains the kringle 2 (K2) domain, and the catalytic domain, which is also referred to as prethrombin-2 (Pre-2). The cleavage sites for activation of prothrombin by FXa (Arg271 and Arg320) are indicated with arrows. The close-up image of the K2 domain is shown with its amino acid sequence. Ser1 of K2 corresponds to Ser156 of full-length prothrombin sequence numbering. The seven residues identified using heteronuclear NMR in our study are highlighted in red.