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. 2019 Feb 21;9:2436. doi: 10.1038/s41598-019-38857-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of FXa-mediated prothrombin activation by synthetic peptides derived from F2. (A) Relative rates of prothrombin activation in the presence of 300 nM prothrombin, 5 mM CaCl₂, 5 μM DAPA, 50 μM PCPS, and F2P1 (triangles), F2P2 (circles), F2P3 (squares) or F2P8 (diamonds) at varying concentration are plotted with respect to inhibitor concentrations. Reactions were started by addition of 20 nM FXa. (B) Prothrombin activation was carried out as above, but in the presence of 5 nM FVa and F2P2 (circles), or F2P3 (squares) at varying concentrations. Reactions were initiated by addition of 0.1 nM FXa. Non-linear regression analysis was carried out to determine the IC₅₀ and the apparent K_i was calculated using the Cheng-Prusoff equation.