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. 2019 Feb 22;9:2546. doi: 10.1038/s41598-019-38756-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Vitamin D, DHCR7 and lipid profiles upon TNFa-blockade in RA. (A) Changes in DAS28, vitamin D and DHCR7 in patients following TNFa-blockade therapy for 3 months. Values before the initiation of the treatment (baseline, BL) and after treatment (post-treatment, PT) were evaluated by Wilcoxon paired tests. BL and PT medians (interquartile range) for each of the variables analyzed was included at the top of each graph. (B) Associations between the change (PT minus BL) in serum vitamin D levels and DAS28 as well as in DHCR7 serum levels. (C) Correlation between the total-/HDL-cholesterol ratio and DHCR7 serum levels before (BL) and after (PT) treatment. Correlations were evaluated by Spearman rank’s tests.