Table 4.
Effect of vitamin D deficiency on clinical features and lipid profile depending on VDR rs2228570 status.
| GG (n = 71) | AG/AA (n = 123) | |||
|---|---|---|---|---|
| Mean difference (95% CI) | p-value | Mean difference (95% CI) | p-value | |
| A) Clinical features | ||||
| Disease activity (DAS28) | −0.291 (−1.075, 0.492) | 0.466 | 0.704 (0.126, 1.281) | 0.018 |
| Tender Joint Count | −0.243 (−5.420, 0.570) | 0.112 | 2.92 (0.890, 4.930) | 0.005 |
| Swollen Joint Count | −1.320 (−3.250, 0.620) | 0.182 | 1.960 (0.73, 3.190) | 0.002 |
| Patient Global Assessment | −2.490 (−15.820, 10.820) | 0.714 | 6.970 (−3.210, 17.150) | 0.179 |
| ESR | 2.702 (−7.325, 12.736) | 0.597 | 1.716 (−7.868, 11.302) | 0.726 |
| CRP | 0.780 (−0.382, 0.538) | 0.740 | −0.016 (−0.322, 0.354) | 0.925 |
| HAQ | 0.012 (−0.363, 0.387) | 0.950 | 0.306 (0.041, 0.572) | 0.024 |
| Pain assessment | −1.260 (−3.350, 0.840) | 0.240 | 0.890 (−0.140, 1.930) | 0.092 |
| B) Lipid profile | ||||
| Total-cholesterol | −11.491 (−29.913, 6.930) | 0.221 | 3.538 (−9.727, 16.803) | 0.601 |
| HDL-cholesterol | −5.045 (−13.923, 3.832) | 0.265 | −7.363 (−13.936, −0.790) | 0.028 |
| LDL-cholesterol | −7.36 (−24.324, 9.592) | 0.395 | 0.429 (−12.72, 13.568) | 0.949 |
| Total-/HDL-cholesterol ratio | 0.283 (−0.330, 0.890) | 0.365 | 0.575 (0.098, 1.052) | 0.018 |
| Triglycerides | −28.75 (−82.328, 24.827) | 0.293 | 68.732 (0.566, 136.897) | 0.048 |
The effect of vitamin D deficiency was analyzed by multiple linear regression analyses adjusted by age, gender, seasonality, vitamin D supplementation and DMARD usage (glucocorticoids, methotrexate, TNFα-blockers and tocilizumab). Mean differences and 95% CI were computed for each parameter. Mean differences were referred to the comparison between vitamin D deficiency (<20 ng/ml) vs. no deficiency (>20 ng/ml).