Fig. 2. MIM1 induces NOXA via activation of ATF3 and ATF4.

a NB4 cells were incubated with 25 µM MIM1 for 0–6 h and analyzed for markers of UPR via western blotting. b NB4 cells were co-transfected with siRNA against ATF3 and ATF4 then incubated with 25 µM MIM1 for 6 h. c NB4 cells were incubated with 0–50 µM MIM1 for 6 h and NOXA mRNA was quantified via qPCR. Error bars represent 1 standard deviation of the mean (n = 3, ^*p < 0.05)