Fig. 1.

Stat1^−/− T cells fail to induce colitis due to defective expansion. Il10rb^−/−Rag1^−/− mice were injected i.p. with 1 × 10⁶ unfractionated WT or Stat1^−/− CD4⁺ T cells. a Mean % original body weights ± SEM following T-cell transfer. Source data are provided as a Source Data file. b Representative images of colons, as well as representative H&E images of distal colon sections with mean histological scores ± SEM at 3 weeks post transfer. Scale bar represents 200 µm. c, d Representative flow cytometry plots of CD4⁺ T cells (gated on live CD45⁺ cells, Supplementary Fig. 4a) in the c colon and d spleen followed by their mean frequencies ± SEM at 3 weeks post transfer. All data are pooled from two to three independent experiments, with each point representing an individual mouse. ****p < 0.0001, ***p < 0.001 by a two-way ANOVA with Bonferroni’s correction or b–d two-tailed Mann–Whitney test