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. 2019 Feb 21;10(3):180. doi: 10.1038/s41419-019-1429-0

Fig. 1. Kv11.1 stimulation inhibits primary tumor growth and metastasis in\ a xenograft model of breast cancer.

Fig. 1

MDA-MB-231 cells were injected subcutaneously into the dorsal flank of NSG mice. When tumors were palpable, the mice were injected intraperitoneally with vehicle alone or Kv11.1 activator NS1643 at 6 mg/kg every 2 days. a Mean tumor volume in mice treated with either vehicle control (n = 12) or Kv11.1 activator (NS1643) (n = 12). b Barchart showing the absolute frequencies of liver macrometastases observed in mice treated with either vehicle control or NS1643. c Representative images of livers demonstrating macrometastases in mice treated with either vehicle control or NS1643. d Representative confocal images of human nuclear antigen (HNA; red) and nuclei (DAPI; blue) expression in liver tissue sections from mice treated with either vehicle control or NS1643. e Representative western blot images of HNA expression in liver and (f) lung homogenates from mice treated with either vehicle control or NS1643. Quantification of the levels of HNA protein was done using NIH ImageJ software. Data is expressed as mean ± SEM; *p < 0.05; **p < 0.001)