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. 2019 Feb 22;9:2621. doi: 10.1038/s41598-019-39191-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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FITC-insulin was intranasally administered and imaged in the trigeminal nerve 30 min later (B,E,H). Axons in the trigeminal nerve were labeled with the pan-neuronal marker Neuro-Chrom (A,D,G). The merged images (C,F,I) show FITC-insulin in the perineural spaces of the trigeminal nerve. These data suggest FITC-insulin reaches the CNS along perineural spaces of the trigeminal nerve. Scale bar = 10 μm.