Table 1.
Laboratory tests
| Tests | Reference range | 5 weeks | 2 months | 6.5 months | 9 months | 11 months | 14 months | 16 months | 18 months |
|---|---|---|---|---|---|---|---|---|---|
| Liver function tests | |||||||||
| Bilirubin total (mg/dL) | < 1 | 11.95 | 15.5 | 4.3 | 1.6 | 1.3 | 2.2 | 2.5 | 2.8 |
| Conjugated bilirubin (mg/dL) | < 0.2 | 6.68 | 13.5 | 4.1 | 1.5 | 1.2 | 2.1 | 2.2 | 2.4 |
| AST (IU/L) | < 50 | 210 | 276 | 86 | 75 | 92 | 189 | 135 | 87 |
| ALT (IU/L) | < 40 | 320 | 349 | 47 | 63 | 90 | 332 | 177 | 77 |
| GGT (IU/L) | < 50 | 221 | 1631 | 986 | 872 | 1129 | 1629 | 969 | 657 |
| bile acids (mg/dL) | < 10 | – | 150 | 264 | – | 117 | 304 | 253 | 132 |
| Albumin (g/dL) | 3.6–5.2 | – | 3.7 | 3.3 | 3.7 | 4 | 4 | 4.2 | 4.2 |
| Cholesterol (mg/dL) | < 200 | – | 361 | – | 270 | – | 349 | 256 | – |
| HDL cholesterol (mg/dL) | > 40 | - | - | - | - | - | 133 | 101 | - |
| LDL cholesterol (mg/dL) | < 90 | - | - | - | - | - | 179 | 131 | - |
| Triglycerides (mg/dL) | < 105 | – | – | 135 | 138 | 119 | 187 | 120 | 78 |
| Kidney function tests | |||||||||
| Serum creatinine (mg/dL) | 0.18–0.33 | 0.58 | – | 0.5 | 0.51 | 0.5 | 0.47 | 0.46 | 0.50 |
| eGFR* (ml/min/1.73m2) | 37 | – | 55 | 56 | 62 | 66 | 67 | 66 | |
| Uric acid (mg/dL) | < 6 | – | – | – | 3.6 | 3.8 | 3.2 | 2.5 | 2.8 |
| PrU/CrU** (mg/mg) | < 0.2 | 1.7 | – | 0 | 0 | 0 | 0 | 0.2 | 0 |
| Hemoglobin (g/dL) | 10.5–13.5 | – | 9 | 10.7 | 9.9 | 13.6 | 11.1 | 11.6 | 10.8 |
*estimated glomerular filtration rate (Schwartz’s eGFR = 0.413 x length/sCr)
**proteinuria/creatininuria index