Fig. 3.

dStruct had a low false-positive rate in null comparisons. In a comparison of biological replicates of rRNAs probed in vivo under identical conditions, a dStruct and RASA reported 3 and 4 false positives, respectively. In contrast, PARCEL and deltaSHAPE reported 61 and 97 false positives, respectively. b dStruct had lower nucleotide-level false-positive rates than RASA, PARCEL, and deltaSHAPE