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. 2019 Feb 22;9:2594. doi: 10.1038/s41598-019-39141-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pathway Analysis Following Mild and Moderate IOP. Ingenuity Pathway Analysis of Mild and Moderate IOP compared to Control. (a,c) Heatmap of the significant changes to the canonical pathway (a) and disease/bio functions (c) filtered by −log (P-value). (b,d) Activation z-score directionality graph of the top significant (−log (P-value) > 1.3) canonical pathways (b) and disease/bio functions (d) for both Mild and Moderate IOP elevation. Canonical pathways and disease/bio functions with a Z-score ≥ |2| are significant, were a positive value is considered to be activated and a negative value is considered to be inactivated.