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. 2019 Feb 21;9:2479. doi: 10.1038/s41598-019-39380-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Isocaloric intermittent fasting does not modify body weight in ob/ob mice. (A) An experiment scheme of the 2:1 intermittent fasting (IF) regimen. (B) Daily energy intake during 16 weeks of IF cycles. (C) Total energy intake during 16 weeks of IF cycles. (D) Body weight measurement of ob/ob mice for 16 weeks. (E) Body composition of fat and lean mass in ob/ob mice subjected to the ad libitum (Ob-AL), ob/ob mice subjected to the pair-fed ad libitum (Ob-PF) and ob/ob mice subjected to the intermittent fasting (Ob-IF). Data are expressed as mean ± s.e.m. (Ob-AL: n = 4; Ob-PF: n = 7; Ob-IF: n = 6); Ob-AL vs. Ob-PF: ^$P < 0.05; Ob-AL vs. Ob-IF: ^#P < 0.05; Ob-PF vs. Ob-IF: *P < 0.05.