Table 1.
Top ten up- and down-regulated genes during fracture healing between time points post fracture.
| 5DPF vs Unfractured | 10DPF vs 5 DPF | 20 DPF v 10 DPF | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5-Months Old | 25-Months Old | 5-Months Old | 25-Months Old | 5-Months Old | 25-Months Old | |||||||||||||
| Gene Name |
Fold Change |
q-value | Gene Name |
Fold Change |
q-value | Gene Name |
Fold Change |
q-value | Gene Name | Fold Change |
q-value | Gene Name | Fold Change |
q-value | Gene Name | Fold Change |
q-value | |
| Upregulated Genes | Ccl8 | 51.7068 | 5.46E-13 | Timp1 | 16.319 | 8.89E-12 | Clec3a | 32.8468 | 2.10E-07 | Clec3a | 72.6445 | 1.80E-09 | Car1 | 7.60468 | 0.00347466 | Car1 | 25.0829 | 1.85E-05 |
| Ccl7 | 23.0152 | 2.70E-10 | Tnfaip6 | 15.7304 | 1.02E-10 | Col10a1 | 25.5779 | 2.87E-09 | Col10a1 | 33.574 | 2.17E-10 | Ctse | 4.21029 | 0.0215834 | Gypa | 17.9 | 0.000184688 | |
| Timp1 | 19.4469 | 1.83E-12 | Ccl7 | 15.6649 | 3.29E-09 | Matn3 | 11.3424 | 1.12E-06 | Matn3 | 27.0598 | 2.36E-09 | Car2 | 4.02812 | 0.0117012 | Rhag | 17.677 | 0.000119596 | |
| Serpine1 | 18.7733 | 8.26E-13 | Prg4 | 14.4678 | 2.87E-08 | Lect1 | 11.2742 | 2.19E-07 | Lect1 | 22.9154 | 7.47E-10 | Gdpd2 | 4.01189 | 4.90E-05 | Ctse | 15.9103 | 4.13E-05 | |
| Tnfaip6 | 18.532 | 3.26E-11 | Serpine1 | 14.4383 | 8.89E-12 | Scrg1 | 11.1695 | 4.76E-06 | Hapln1 | 19.6306 | 1.42E-06 | Cldn13 | 3.87113 | 0.0223476 | Car2 | 12.9331 | 2.11E-05 | |
| Sfrp1 | 18.0681 | 4.70E-10 | Cthrc1 | 14.1115 | 2.96E-09 | Hapln1 | 10.8943 | 5.57E-05 | Acan | 16.6014 | 1.51E-06 | Stab2 | 3.75166 | 1.10E-05 | Slc4a1 | 12.1416 | 0.000588406 | |
| Saa3 | 17.6519 | 1.26E-10 | Vcan | 13.6722 | 8.89E-12 | Zim1 | 7.14084 | 2.87E-09 | Ucma | 15.5522 | 5.89E-10 | Spna1 | 3.55237 | 0.0166092 | Cldn13 | 11.0874 | 0.000127954 | |
| Ms4a6d | 17.2707 | 1.44E-11 | Ccl8 | 12.3968 | 9.52E-10 | Agtr2 | 6.4351 | 4.05E-06 | 3110079O15Rik | 15.2108 | 4.91E-08 | Snca | 3.26757 | 0.00742677 | Epb4.2 | 10.0517 | 0.000131137 | |
| Cxcl5 | 17.0611 | 2.31E-08 | Sfrp1 | 11.2241 | 1.35E-08 | Chad | 6.35486 | 0.000321803 | Scrg1 | 14.6 | 5.74E-07 | Gal | 3.23887 | 0.000977659 | Igk-V1 | 9.9375 | 7.79E-05 | |
| Ccl12 | 16.0445 | 5.79E-13 | Saa3 | 10.7828 | 4.84E-09 | Lipi | 6.19965 | 9.35E-09 | Col9a1 | 13.4898 | 6.44E-11 | Ms4a1 | 3.13358 | 0.00492443 | Kel | 9.14906 | 0.000165466 | |
| Downregulated Genes | Gypa | −36.7476 | 1.16E-06 | Ear1 | −20.2929 | 7.23E-07 | Cxcl5 | −14.468 | 9.92E-07 | Cxcl5 | −11.0661 | 2.37E-06 | C1qtnf3 | −19.9331 | 1.54E-07 | Matn3 | −32.2182 | 1.52E-09 |
| Rhag | −31.0394 | 1.28E-06 | Ear6 | −14.6878 | 1.02E-07 | Arg1 | −10.049 | 2.87E-09 | Cxcl2 | −10.2895 | 8.44E-06 | Scrg1 | −15.8569 | 5.18E-07 | Hapln1 | −23.8115 | 9.30E-07 | |
| Car1 | −29.982 | 1.07E-06 | Vpreb1 | −11.9426 | 1.62E-09 | Saa3 | −9.149 | 3.36E-07 | Saa3 | −6.66003 | 1.82E-06 | Matn3 | −14.8953 | 1.92E-07 | Lect1 | −22.1161 | 1.52E-09 | |
| Cldn13 | −24.9896 | 2.09E-07 | Prg2 | −11.7774 | 2.52E-06 | Cxcl2 | −8.7526 | 4.17E-05 | Car1 | −6.11081 | 0.00622303 | Lect1 | −11.9316 | 1.55E-07 | Scrg1 | −21.246 | 9.87E-08 | |
| Car2 | −22.3932 | 1.11E-07 | Vpreb3 | −11.4993 | 1.05E-09 | Prg4 | −8.4259 | 1.39E-05 | Cd163 | −5.7244 | 5.75E-07 | Hapln1 | −11.3573 | 3.71E-05 | Clec3a | −20.9901 | 1.41E-06 | |
| Ctse | −22.3846 | 9.61E-07 | Ly6g | −10.0661 | 1.36E-05 | Il1rl1 | −6.0817 | 2.03E-06 | Prg4 | −5.33996 | 0.000171637 | AF357355 | −8.56187 | 5.63E-06 | C1qtnf3 | −19.9725 | 9.87E-08 | |
| Kel | −21.8589 | 1.50E-07 | Rhag | −9.62421 | 0.000333338 | Il6 | −5.8171 | 0.000249328 | Gypa | −5.20701 | 0.0188113 | 1500015O10Rik | −8.54579 | 3.60E-07 | Ucma | −17.4602 | 3.72E-10 | |
| Rhd | −21.5165 | 3.67E-07 | Igk-V1 | −9.49088 | 1.30E-05 | Ccl2 | −5.6197 | 1.30E-05 | Arg1 | −5.02311 | 7.91E-07 | Ccl8 | −8.1571 | 4.23E-07 | Acan | −16.2878 | 2.73E-06 | |
| Ly6g | −20.394 | 2.50E-07 | Mcpt8 | −8.78738 | 9.34E-08 | Ms4a4a | −4.8786 | 2.05E-07 | Tspan8 | −5.01726 | 0.000373912 | Mfap4 | −7.54815 | 5.80E-08 | Col9a1 | −12.442 | 2.55E-10 | |
| Ear1 | −20.3285 | 8.70E-07 | Gypa | −8.77516 | 0.00083786 | Cd163 | −4.8702 | 4.33E-06 | Serpina3n | −4.88816 | 7.54E-07 | Zim1 | −7.41162 | 3.88E-09 | 3110079O15Rik | −10.0848 | 1.23E-06 | |
Bold genes are present in both 5 and 25 month