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. Author manuscript; available in PMC: 2019 Feb 22.
Published in final edited form as: J Orthop Res. 2017 Oct 9;36(1):149–158. doi: 10.1002/jor.23652

Table 2.

Top 10 up- and down-regulated between old versus young mice at each time point post-fracture.

25-month vs 5 month
Unfractured 5 Days Post Fracture 10 Days Post Fracture 20 Days Post Fracture
Gene Name Fold Change p-value Gene
Name
Fold Change p-value Gene Name Fold Change p-value Gene
Name
Fold Change p-value
Higher Expression at 25-Months Cxcl9 3.9176 0.0003 Igj 3.88103 0.0006 Ucma 3.21115 1.47E-05 Ccl8 3.72603 5.58E-06
Ccl8 3.82189 1.99E-06 Amy1 3.54147 1.56E-05 Mia1 2.77897 4.05E-05 Cxcl9 3.66272 0.0009
Ubd 3.54092 4.31E-05 Tspan8 2.92372 0.0019 3110079O15Rik 2.42711 0.004 Ccl5 3.52583 0.0003
Ccl5 2.98618 0.0007 Krt18 2.89207 6.70E-05 Scube1 2.13944 4.99E-05 Lcn2 3.15219 0.0015
Csprs 2.61911 3.39E-08 Nrap 2.74706 0.0022 Col9a1 2.13406 0.0004 AW112010 2.94374 4.93E-05
Rtp4 2.55427 6.54E-05 Camk2b 2.63232 8.52E-06 Moxd1 2.07754 0.0029 Pglyrp1 2.72714 0.0012
Oasl2 2.52529 6.00E-05 Cmya5 2.62953 0.0013 Col9a3 2.00654 0.0001 Apol10a 2.66505 0.0016
Gm7609 2.50707 6.22E-08 Trdn 2.56702 0.0049 Matn1 1.95358 1.54E-05 Ms4a4b 2.64142 0.0001
Nlrc5 2.4735 4.46E-06 Fsd2 2.53774 0.001 Cspg4 1.8078 0.004 Klrc1 2.63664 0.0032
Gm7609 2.45712 2.48E-08 Gm10674 2.51765 0.0015 Mfge8 1.80739 0.0003 Lrg1 2.61073 0.0008
Lower Expression at 25-Months Adamts3 −1.66205 0.001 Mir99a −3.10473 0.0003 Mup7 −4.62095 0.0032 Vpreb1 −2.29738 0.0019
Rag2 −1.62362 0.0003 Snora73a −3.06453 0.0002 Mup11 −4.4348 0.0028 Hmcn1 −2.1022 0.0003
Mepe −1.59314 0.004 Snora73b −3.03144 0.0002 Mup19 −4.23417 0.0031 Igll1 −1.85577 0.0015
Zfp521 −1.51664 0.004 Snora44 −2.74157 0.001 Mup2 −4.11126 0.0031 Snord52 −1.82012 0.0002
Eif2b3 −1.40897 0.0002 Crabp1 −2.69092 1.55E-05 Mup1 −3.26439 0.0031 Hmcn1 −1.70504 0.0038
2310047B19Rik −1.3452 0.0006 Npm3 −2.04601 1.56E-05 Snord118 −2.74323 0.0005 Syne2 −1.61705 0.0015
2700097O09Rik −1.33643 0.0032 Fcrls −2.03889 2.11E-05 Adipoq −2.49978 0.0009 Hmcn1 −1.58635 0.0033
Etv1 −1.33367 0.0001 Mir15a −1.99839 0.0029 Mcpt4 −2.38792 3.50E-06 Prss48 −1.57496 0.0001
Epha4 −1.31656 0.0022 Mir15a −1.98857 0.0002 Snora23 −2.26599 0.0035 Arhgef5 −1.5678 0.0005
Mrpl21 −1.28749 0.0005 Arsi −1.92852 0.0007 Vpreb1 −2.17515 0.0034 Fign −1.55236 0.0004