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. Author manuscript; available in PMC: 2020 Jan 28.
Published in final edited form as: J Control Release. 2018 Nov 27;294:53–76. doi: 10.1016/j.jconrel.2018.11.024

Figure 5.

Figure 5.

(a) Synthesis of pH-responsive magnetic CNC-based nanocarrier. The nanocellulose was reacted with tosylchloride for the functionalization with tris(2-aminoethyl)amine (AMFC), providing amino groups to effectively attract the carboxyl groups of methotrexate (MTX, an anticancer drug). The magnetic CNC-based MTX delivery system, fabricated by an in situ reaction with FeCl2 and FeCl3, provides AMFC-coated magnetic nanoparticles (AMFC@MNPs), which are responsive to pH. (b) MTX-loaded magnetic CNC carriers, benefitting from the similarity of MTX to folic acid, faciliatet the folate receptor-mediated cell internalization [82]. Reproduced from [82] with permission from the Centre National de la Recherche Scientifique (CNRS) and The Royal Society of Chemistry.